HIV / AIDS symptoms

HIV / AIDS symptoms

HIV / AIDS symptoms – published by EMWA – Elite Medical Welfare Association

Within a month or two of HIV entering the body, 40% to 90% of people experience flulike symptoms known as acute retroviral syndrome (ARS). But sometimes HIV symptoms don’t appear for years—sometimes even a decade—after infection.

“In the early stages of HIV infection, the most common symptoms are none,” says Michael Horberg, MD, director of HIV/AIDS for Kaiser Permanente, in Oakland, Calif. One in five people in the United States with HIV doesn’t know they have it, which is why it’s so important to get tested, especially if you have unprotected sex with more than one partner or use intravenous drugs.

Here are some signs that you may be HIV-positive.

Fever

One of the first signs of ARS can be a mild fever, up to about 102 degrees F.

The fever, if it occurs at all, is often accompanied by other usually mild symptoms, such as fatigue, swollen lymph glands, and a sore throat.

“At this point the virus is moving into the blood stream and starting to replicate in large numbers,” says Carlos Malvestutto, MD, instructor of infectious diseases and immunology in the department of medicine at NYU School of Medicine in New York City. “As that happens, there is an inflammatory reaction by the immune system.”

Fatigue

The inflammatory response generated by your besieged immune system also can cause you to feel tired and lethargic. Fatigue can be both an early and later sign of HIV.

Ron, 54, a public relations executive in the Midwest, started to worry about his health when he suddenly got winded just walking. “Everything I did, I got out of breath,” he says. “Before that I had been walking three miles a day.”

Ron had tested HIV positive 25 years before feeling so tired; fatigue during acute, or newly contracted, HIV might not be so obvious.

Achy muscles, joint pain, swollen lymph nodes

ARS is often mistaken for the flu, mononucleosis, or another viral infection, even syphilis or hepatitis.

That’s not surprising: Many of the symptoms are the same, including pain in the joints and muscles and swollen lymph glands.

Lymph nodes are part of your body’s immune system and tend to get inflamed when there’s an infection. Many of them are located in your armpit, groin, and neck.

Sore throat and headache

As with other symptoms, sore throat and headache can often be recognized as ARS only in context, Dr. Horberg says.

If you’ve engaged recently in high-risk behavior, an HIV test is a good idea. Get tested for your own sake and for others: HIV is most infectious in the earliest stage.

Keep in mind that the body hasn’t produced antibodies to HIV yet so an antibody test may not pick it up. (It can take a few weeks to a few months for HIV antibodies to show in a blood test). Investigate other test options such as one that detects viral RNA, typically within nine days of infection.

Skin rash

Skin rashes can occur early or late in the course of HIV/AIDS.

For Ron, this was another sign that he might not have run-of-the-mill allergies or a cold.

“They were like boils, with some itchy pink areas on my arms,” Ron says. The rashes can also appear on the trunk of the body. “If [the rashes] aren’t easily explained or easily treated, you should think about having an HIV test,” Dr. Horberg says.

Nausea, vomiting, diarrhea

Anywhere from 30% to 60% of people have short-term nausea, vomiting, or diarrhea in the early stages of HIV, Dr. Malvestutto says.

These symptoms can also appear as a result of antiretroviral therapy and later in the infection, usually as the result of an opportunistic infection.

“Diarrhea that is unremitting and not responding at all to usual therapy might be an indication,” Dr. Horberg says. Or symptoms may be caused by an organism not usually seen in people with healthy immune systems, he adds.

Weight loss

Once called “AIDS wasting,” weight loss is a sign of more advanced illness and could be due in part to severe diarrhea.

“If you’re already losing weight, that means the immune system is usually fairly depleted,” Dr. Malvestutto says. “This is the patient who has lost a lot of weight even if they continue to eat as much as possible. This is late presentation. We still see a lot of these.” It has become less common, however, thanks to antiretroviral therapy.

A person is considered to have wasting syndrome if they lose 10% or more of their body weight and have had diarrhea or weakness and fever for more than 30 days, according to the U.S. Department of Health and Human Services.

Dry cough

A dry cough was the first sign Ron had that something was wrong. He at first dismissed it as bad allergies.

But it went on for a year and a half—and kept getting worse. Benadryl, antibiotics, and inhalers didn’t fix the problem. Neither did allergists.

This symptom—an “insidious cough that could be going on for weeks that doesn’t seem to resolve,” Dr. Malvestutto says—is typical in very ill HIV patients.

Pneumonia

The cough and the weight loss may also presage a serious infection caused by a germ that wouldn’t bother you if your immune system was working properly.

“There are many different opportunistic infections and each one can present differently,” Dr. Malvestutto says. In Ron’s case, it was Pneumocystis pneumonia (PCP), aka “AIDS pneumonia,” which eventually landed him in the hospital.

Other opportunistic infections include toxoplasmosis, a parasitic infection that affects the brain; a type of herpes virus called cytomegalovirus; and yeast infections such as thrush.

Night sweats

About half of people get night sweats during the early stages of HIV infection, Dr. Malvestutto says.

These can be even more common later in infection and aren’t related to exercise or the temperature of the room.

Similar to the hot flashes that menopausal women suffer, they’re also hard to dismiss, given that they soak your bedclothes and sheets.

Nail changes

Another sign of late HIV infection are nail changes, such as clubbing (thickening and curving of the nails), splitting of the nails, or discoloration (black or brown lines going either vertically or horizontally).

Often this is due to a fungal infection, such as candida. “Patients with depleted immune systems will be more susceptible to fungal infections,” Dr. Malvestutto says.

Yeast infections

Another fungal infection that’s common in later stages is thrush, a mouth infection caused by Candida, a type of yeast.

“It’s a very common fungus and the one that causes yeast infections in women,” Dr. Malvestutto says. “They tend to appear in the mouth or esophagus, making it difficult to swallow.”

Ron woke up one day to find white patches on his tongue. He had thrush. For him, “It was not bothersome other than I didn’t like having it.” The infection was hard to get rid of, but finally cleared up after Ron started taking drugs to combat HIV.

Confusion or difficulty concentrating

Cognitive problems could be a sign of HIV-related dementia, which usually occurs late in the course of the disease.

In addition to confusion and difficulty concentrating, AIDS-related dementia might also involve memory problems and behavioral issues such as anger or irritability.

It may even include motor changes: becoming clumsy, lack of coordination, and problems with tasks requiring fine motor skills such as writing by hand.

Cold sores or genital herpes

Cold sores (oral herpes) and genital herpes can be a sign of both ARS and late-stage HIV infection.

And having herpes can also be a risk factor for contracting HIV. This is because genital herpes can cause ulcers that make it easier for HIV to enter the body during sex. And people who have HIV tend to have more severe herpes outbreaks more often because HIV weakens the immune system.

Tingling and weakness

Late HIV can also cause numbness and tingling in the hands and feet. This is called peripheral neuropathy, which also occurs in people with uncontrolled diabetes.

“This is when the nerves are actually damaged,” Dr. Malvestutto says. These symptoms can be treated with over-the-counter pain relievers and antiseizure medicines such as Neurontin (gabapentin).

Menstrual irregularities

Advanced HIV disease appears to increase the risk of having menstrual irregularities, such as fewer and lighter periods.

These changes, however, probably have more to do with the weight loss and poor health of women with late-stage infection rather than the infection itself.

Infection with HIV also has been associated with earlier age of menopause (47 to 48 years for infected women compared to 49 to 51 years for uninfected women).

HIV / AIDS symptoms – published by EMWA – Elite Medical Welfare Association

SOURCE: http://www.health.com/health/gallery/0,,20539037,00.html

AIDS Precautions for clinical Staff – EMWA

AIDS Precautions for clinical staff by EMWA

The etiology of the underlying immune deficiencies seen in AIDS cases is unknown. One hypothesis consistent with current observations is that a transmissible agent may be involved. If so, transmission of the agent would appear most commonly to require intimate, direct contact involving mucosal surfaces, such as sexual contact among homosexual males, or through parenteral spread, such as occurs among intravenous drug abusers and possibly hemophilia patients using Factor VIII products. Airborne spread and interpersonal spread through casual contact do not seem likely. These patterns resemble the distribution of disease and modes of spread of hepatitis B virus, and hepatitis B virus infections occur very frequently among AIDS cases.

There is presently no evidence of AIDS transmission to hospital personnel from contact with affected patients or clinical specimens. Because of concern about a possible transmissible agent, however, interim suggestions are appropriate to guide patient-care and laboratory personnel, including those whose work involves experimental animals. At present, it appears prudent for hospital personnel to use the same precautions when caring for patients with AIDS as those used for patients with hepatitis B virus infection, in which blood and body fluids likely to have been contaminated with blood are considered infective. Specifically, patient-care and laboratory personnel should take precautions to avoid direct contact of skin and mucous membranes with blood, blood products, excretions, secretions, and tissues of persons judged likely to have AIDS. The following precautions do not specifically address outpatient care, dental care, surgery, necropsy, or hemodialysis of AIDS patients. In general, procedures appropriate for patients known to be infected with hepatitis B virus are advised, and blood and organs of AIDS patients should not be donated.

The precautions that follow are advised for persons and specimens from persons with: opportunistic infections that are not associated with underlying immunosuppressive disease or therapy; Kaposi’s sarcoma (patients under 60 years of age); chronic generalized lymphadenopathy, unexplained weight loss and/or prolonged unexplained fever in persons who belong to groups with apparently increased risks of AIDS (homosexual males, intravenous drug abusers, Haitian entrants, hemophiliacs); and possible AIDS (hospitalized for evaluation). Hospitals and laboratories should adapt the following suggested precautions to their individual circumstances; these recommendations are not meant to restrict hospitals from implementing additional precautions.

  1. The following precautions are advised in providing care to AIDS patients:
    1. Extraordinary care must be taken to avoid accidental wounds from sharp instruments contaminated with potentially infectious material and to avoid contact of open skin lesions with material from AIDS patients.
    2. Gloves should be worn when handling blood specimens, blood-soiled items, body fluids, excretions, and secretions, as well as surfaces, materials, and objects exposed to them.
    3. Gowns should be worn when clothing may be soiled with body fluids, blood, secretions, or excretions.
    4. Hands should be washed after removing gowns and gloves and before leaving the rooms of known or suspected AIDS patients. Hands should also be washed thoroughly and immediately if they become contaminated with blood.
    5. Blood and other specimens should be labeled prominently with a special warning, such as “Blood Precautions” or “AIDS Precautions.” If the outside of the specimen container is visibly contaminated with blood, it should be cleaned with a disinfectant (such as a 1:10 dilution of 5.25% sodium hypochlorite (household bleach) with water). All blood specimens should be placed in a second container, such as an impervious bag, for transport. The container or bag should be examined carefully for leaks or cracks.
    6. Blood spills should be cleaned up promptly with a disinfectant solution, such as sodium hypochlorite (see above).
    7. Articles soiled with blood should be placed in an impervious bag prominently labeled “AIDS Precautions” or “Blood Precautions” before being sent for reprocessing or disposal. Alternatively, such contaminated items may be placed in plastic bags of a particular color designated solely for disposal of infectious wastes by the hospital. Disposable items should be incinerated or disposed of in accord with the hospital’s policies for disposal of infectious wastes. Reusable items should be reprocessed in accord with hospital policies for hepatitis B virus-contaminated items. Lensed instruments should be sterilized after use on AIDS patients.
    8. Needles should not be bent after use, but should be promptly placed in a puncture-resistant container used solely for such disposal. Needles should not be reinserted into their original sheaths before being discarded into the container, since this is a common cause of needle injury.
    9. Disposable syringes and needles are preferred. Only needle-locking syringes or one-piece needle-syringe units should be used to aspirate fluids from patients, so that collected fluid can be safely discharged through the needle, if desired. If reusable syringes are employed, they should be decontaminated before reprocessing.
    10. A private room is indicated for patients who are too ill to use good hygiene, such as those with profuse diarrhea, fecal incontinence, or altered behavior secondary to central nervous system infections. Precautions appropriate for particular infections that

concurrently occur in AIDS patients should be added to the above, if needed.

B. The following precautions are advised for persons performing laboratory tests or studies on clinical specimens or other potentially infectious materials (such as inoculated tissue cultures, embryonated eggs, animal tissues, etc.) from known or suspected AIDS cases:

  1. Mechanical pipetting devices should be used for the manipulation of all liquids in the laboratory. Mouth pipetting should not be allowed.
  2. Needles and syringes should be handled as stipulated in Section\A (above).
  3. Laboratory coats, gowns, or uniforms should be worn while working with potentially infectious materials and should be discarded appropriately before leaving the laboratory.
  4. Gloves should be worn to avoid skin contact with blood, specimens containing blood, blood-soiled items, body fluids, excretions, and secretions, as well as surfaces, materials, and objects exposed to them.
  5. All procedures and manipulations of potentially infectious material should be performed carefully to minimize the creation of droplets and aerosols.
  6. Biological safety cabinets (Class I or II) and other primary containment devices (e.g., centrifuge safety cups) are advised whenever procedures are conducted that have a high potential for creating aerosols or infectious droplets. These include centrifuging, blending, sonicating, vigorous mixing, and harvesting infected tissues from animals or embryonated eggs. Fluorescent activated cell sorters generate droplets that could potentially result in infectious aerosols. Translucent plastic shielding between the droplet-collecting area and the equipment operator should be used to reduce the presently uncertain magnitude of this risk. Primary containment devices are also used in handling materials that might contain concentrated infectious agents or organisms in greater quantities than expected in clinical specimens.
  7. Laboratory work surfaces should be decontaminated with a disinfectant, such as sodium hypochlorite solution (see A5 above), following any spill of potentially infectious material and at the completion of work activities.
  8. All potentially contaminated materials used in laboratory tests should be decontaminated, preferably by autoclaving, before disposal or reprocessing.
  9. All personnel should wash their hands following completion of laboratory activities, removal of protective clothing, and before leaving the laboratory. C. The following additional precautions are advised for studies involving experimental animals inoculated with tissues or other potentially infectious materials from individuals with known or suspected AIDS.
  10. Laboratory coats, gowns, or uniforms should be worn by personnel entering rooms housing inoculated animals. Certain nonhuman primates, such as chimpanzees, are prone to throw excreta and to spit at attendants; personnel attending inoculated animals should wear molded surgical masks and goggles or other equipment sufficient to prevent potentially infective droplets from reaching the mucosal surfaces of their mouths, nares, and eyes. In addition, when handled, other animals may disturb excreta in their bedding. Therefore, the above precautions should be taken when handling them.
  11. Personnel should wear gloves for all activities involving direct contact with experimental animals and their bedding and cages. Such manipulations should be performed carefully to minimize the creation of aerosols and droplets.
  12. Necropsy of experimental animals should be conducted by personnel wearing gowns and gloves. If procedures generating aerosols are performed, masks and goggles should be worn.
  13. Extraordinary care must be taken to avoid accidental sticks or cuts with sharp instruments contaminated with body fluids or tissues of experimental animals inoculated with material from AIDS patients.
  14. Animal cages should be decontaminated, preferably by autoclaving, before they are cleaned and washed.
  15. Only needle-locking syringes or one-piece needle-syringe units should be used to inject potentially infectious fluids into experimental animals. The above precautions are intended to apply to both clinical and

research laboratories. Biological safety cabinets and other safety equipment may not be generally available in clinical laboratories. Assistance should be sought from a microbiology laboratory, as needed, to assure containment facilities are adequate to permit laboratory tests to be conducted safely. Reported by Hospital Infections Program, Div of Viral Diseases, Div of Host Factors, Div of Hepatitis and Viral Enteritis, AIDS Activity, Center for Infectious Diseases, Office of Biosafety, CDC; Div of Safety, National Institutes of Health.

SOURCE: http://www.cdc.gov/mmwr/preview/mmwrhtml/00001183.htm